{"id":441,"date":"2025-10-14T22:25:55","date_gmt":"2025-10-14T13:25:55","guid":{"rendered":"https:\/\/dr-kosodate-ns.com\/?p=441"},"modified":"2025-10-14T22:25:55","modified_gmt":"2025-10-14T13:25:55","slug":"2025%e5%b9%b4%e3%83%8e%e3%83%bc%e3%83%99%e3%83%ab%e7%94%9f%e7%90%86%e5%ad%a6%e3%83%bb%e5%8c%bb%e5%ad%a6%e8%b3%9e%e3%80%8c%e6%9c%ab%e6%a2%a2%e6%80%a7%e5%85%8d%e7%96%ab%e5%af%9b%e5%ae%b9%e3%80%8d","status":"publish","type":"post","link":"https:\/\/dr-kosodate-ns.com\/?p=441","title":{"rendered":"2025\u5e74\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u300c\u672b\u68a2\u6027\u514d\u75ab\u5bdb\u5bb9\u300d\u3068\u306f\uff1f\uff1a\u81ea\u5206\u3092\u9593\u9055\u3063\u3066\u653b\u6483\u3057\u306a\u3044\u305f\u3081\u306e\u76e3\u8996\u5f79\u300c\u5236\u5fa1\u6027T\u7d30\u80de\u300d\u306e\u306f\u305f\u3089\u304d\u3068\u4eca\u5f8c\u3002\u4f55\u306b\u5f79\u7acb\u3064\u306e\u304b\u3001\u7cbe\u795e\u795e\u7d4c\u79d1\u3068\u306e\u95a2\u9023\u306f\u3042\u308b\u306e\u304b"},"content":{"rendered":"\n<p>\u3053\u3093\u306b\u3061\u306f\u3001Dr.\u6d41\u661f\u3067\u3059\u3002<\/p>\n\n\n\n<p>2025\u5e7410\u6708\u3001\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u306f\u300c\u672b\u68a2\u6027\u514d\u75ab\u5bdb\u5bb9\uff08Peripheral Immune Tolerance\uff09\u300d\u306b\u95a2\u3059\u308b\u753b\u671f\u7684\u306a\u767a\u898b\u306b\u8d08\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u8cde\u3092\u53d7\u3051\u305f\u306e\u306f\u3001\u30a2\u30e1\u30ea\u30ab\u306e\u30e1\u30a2\u30ea\u30fc\u30fbE\u30fb\u30d6\u30e9\u30f3\u30b3\u30fc\u6c0f\u3001\u30d5\u30ec\u30c3\u30c9\u30fb\u30e9\u30e0\u30ba\u30c7\u30eb\u6c0f\u3001\u305d\u3057\u3066\u65e5\u672c\u30fb\u5927\u962a\u5927\u5b66\u306e\u514d\u75ab\u5b66\u8005\u3067\u3042\u308b\u5742\u53e3\u5fd7\u6587\uff08\u3055\u304b\u3050\u3061\u3057\u3082\u3093\uff09\u6c0f\u306e3\u540d\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5f7c\u3089\u306f<strong>\u79c1\u305f\u3061\u306e\u5f37\u529b\u306a\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u66b4\u8d70\u3057\u3066\u81ea\u3089\u306e\u4f53\u3092\u653b\u6483\u3057\u306a\u3044\u3088\u3046\u306b\u8abf\u7bc0\u3059\u308b\u3057\u304f\u307f<\/strong>\u3001\u3059\u306a\u308f\u3061\u300c\u672b\u68a2\u6027\u514d\u75ab\u5bdb\u5bb9\u300d\u3092\u767a\u898b\u30fb\u89e3\u660e\u3057\u307e\u3057\u305f\u3002\u3067\u306f\u3001\u3053\u306e\u300c\u514d\u75ab\u5bdb\u5bb9\u300d\u3068\u306f\u4f55\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n\n\n\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u672b\u68a2\u6027\u514d\u75ab\u5bdb\u5bb9\u306e\u5b9a\u7fa9\u3084\u50cd\u304d\u3001\u305d\u3057\u3066\u81e8\u5e8a\u7684\u306a\u610f\u7fa9\u306b\u3064\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002\u7cbe\u795e\u79d1\u533b\u306e\u8996\u70b9\u304b\u3089\u3001\u514d\u75ab\u5bdb\u5bb9\u3068\u5fc3\u306e\u95a2\u308f\u308a\u306b\u3064\u3044\u3066\u3082\u5c11\u3057\u89e6\u308c\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-black-color has-text-color has-link-color 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tolerance\uff09<\/strong>\u3067\u3059\u3002\u672b\u68a2\uff08\uff1d\u5168\u8eab\u306e\u3042\u3061\u3053\u3061\uff09\u3067\u50cd\u304f\u514d\u75ab\u5bdb\u5bb9\u306e\u3057\u304f\u307f\u304c\u3001\u5352\u696d\u5f8c\u306e\u514d\u75ab\u7d30\u80de\u305f\u3061\u3092\u898b\u5f35\u308a\u3001\u4e07\u304c\u4e00\u3001\u81ea\u5df1\u653b\u6483\u3092\u59cb\u3081\u305d\u3046\u306a\u7d30\u80de\u304c\u3042\u308c\u3070\u300c\u5f85\u3066\u5f85\u3066\u3002\u653b\u6483\u3057\u305f\u3089\u30c0\u30e1\u3060\u3088\u300d\u3068\u30b9\u30c8\u30c3\u30d7\u3092\u304b\u3051\u3066\u304f\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-black-color has-text-color has-link-color wp-elements-66fbb8fb7f7c9717c16a837864ea0a71\">\u672b\u68a2\u6027\u514d\u75ab\u5bdb\u5bb9\u3092\u62c5\u3046\u300c\u5236\u5fa1\u6027T\u7d30\u80de\u300d\u3068\u3044\u3046\u76e3\u8996\u5f79<\/h2>\n\n\n\n<p>\u3067\u306f\u3001\u3053\u306e\u7b2c2\u306e\u898b\u5f35\u308a\u5f79\u3068\u306f\u5177\u4f53\u7684\u306b\u3069\u3093\u306a\u3082\u306e\u306a\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u30ce\u30fc\u30d9\u30eb\u8cde\u53d7\u8cde\u8005\u305f\u3061\u306e\u767a\u898b\u306b\u3088\u308a\u3001\u305d\u306e\u6b63\u4f53\u304c<strong>\u300c\u5236\u5fa1\u6027T\u7d30\u80de\uff08regulatory T cell, 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href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/press-release\/#:~:text=Two%20years%20after%20this%2C%20Shimon,system%20tolerates%20our%20own%20tissues\" target=\"_blank\" rel=\"noreferrer 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wp-elements-fae5bb4dc7ac863709bdae941501a530\">\u307e\u3068\u3081\uff1a\u514d\u75ab\u306b\u5099\u308f\u308b\u300c\u5bdb\u5bb9\u3055\u300d\u306e\u6069\u6075<\/h2>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u4f53\u306e\u9632\u885b\u8ecd\u3067\u3042\u308b\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u306f\u3001\u5f37\u529b\u3067\u3042\u308b\u304c\u3086\u3048\u306b<strong>\u5473\u65b9\u3068\u6575\u3092\u6b63\u3057\u304f\u898b\u5206\u3051\u308b\u8ce2\u3055<\/strong>\u304c\u6c42\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u514d\u75ab\u5bdb\u5bb9\u3001\u3068\u308a\u308f\u3051\u672b\u68a2\u6027\u514d\u75ab\u5bdb\u5bb9\u306e\u4ed5\u7d44\u307f\u306f\u3001\u514d\u75ab\u306b\u3068\u3063\u3066\u306e\u5473\u65b9\u3092\u50b7\u3064\u3051\u306a\u3044\u305f\u3081\u306e\u91cd\u8981\u306a\u5b89\u5168\u88c5\u7f6e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u30ce\u30fc\u30d9\u30eb\u8cde\u3092\u53d7\u8cde\u3057\u305f\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u305d\u306e\u5b89\u5168\u88c5\u7f6e\u306e\u4e3b\u5f79\u304c<strong>\u5236\u5fa1\u6027T\u7d30\u80de<\/strong>\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3001\u514d\u75ab\u5b66\u306e\u57fa\u672c\u539f\u7406\u304c\u4e00\u6bb5\u3068\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u514d\u75ab\u5bdb\u5bb9\u306e\u304a\u304b\u3052\u3067\u3001\u79c1\u305f\u3061\u306f\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u306a\u308b\u3053\u3068\u306a\u304f\u65e5\u3005\u5065\u5eb7\u306b\u904e\u3054\u305b\u3066\u3044\u307e\u3059\u3057\u3001\u98df\u4e8b\u3092\u3057\u3066\u3082\u6bce\u56de\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3092\u8d77\u3053\u3055\u305a\u306b\u6e08\u3093\u3067\u3044\u307e\u3059\u3002\u3082\u3057\u514d\u75ab\u5bdb\u5bb9\u304c\u306a\u3051\u308c\u3070\u3001\u4f53\u306f\u5e38\u306b\u5185\u6226\u72b6\u614b\u3068\u306a\u308a\u3001\u751f\u304d\u3066\u3044\u304f\u3053\u3068\u3059\u3089\u56f0\u96e3\u3060\u3063\u305f\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u672b\u68a2\u6027\u514d\u75ab\u5bdb\u5bb9\u306e\u767a\u898b\u306f\u533b\u5b66\u306b\u5927\u304d\u306a\u6ce2\u53ca\u52b9\u679c\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u307e\u3059\u3002<strong>\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6cd5<\/strong>\u3001\u81d3\u5668\u79fb\u690d\u306e\u6210\u529f\u7387\u5411\u4e0a\u3001\u3055\u3089\u306b\u306f<strong>\u304c\u3093\u514d\u75ab\u7642\u6cd5\u306e\u767a\u5c55<\/strong>\u306b\u307e\u3067\u7e4b\u304c\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u5236\u5fa1\u6027T\u7d30\u80de\u3092\u5897\u3084\u3059\u6cbb\u7642\u3067\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u6291\u3048\u305f\u308a\u3001\u9006\u306b\u304c\u3093\u60a3\u8005\u3055\u3093\u3067\u306f\u514d\u75ab\u306e\u30d6\u30ec\u30fc\u30ad\u3092\u5916\u3057\u3066\u816b\u760d\u3068\u95d8\u308f\u305b\u305f\u308a\u3068\u3001<strong>\u514d\u75ab\u5bdb\u5bb9\u3092\u64cd\u4f5c\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong>\u304c\u7d9a\u3005\u3068\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u533b\u5b66\u306e\u30b4\u30fc\u30eb\u306f\u3001\u514d\u75ab\u306e\u66b4\u8d70\u3092\u9632\u304e\u3064\u3064\u3001\u305d\u306e\u9632\u885b\u529b\u306f\u5931\u308f\u306a\u3044\u3068\u3044\u3046<strong>\u7d76\u5999\u306a\u30d0\u30e9\u30f3\u30b9\u3092\u7dad\u6301\u3059\u308b\u3053\u3068<\/strong>\u3067\u3059\u3002\u307e\u3055\u306b\u514d\u75ab\u306b\u3068\u3063\u3066\u306e\u300c\u5bdb\u5bb9\u3055\u300d\u3068\u300c\u653b\u6483\u529b\u300d\u306e\u4e21\u7acb\u3092\u3069\u3046\u56f3\u308b\u304b\u304c\u8ab2\u984c\u3068\u8a00\u3048\u307e\u3059\u3002\u3053\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u53ef\u8996\u5316\uff08\u691c\u67fb\uff09\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u304a\u85ac\u306a\u3069\u306e\u6cbb\u7642\u3067\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3082\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308c\u3070\u3001\u3055\u3089\u306b\u4eba\u985e\u306e\u5065\u5eb7\u5bff\u547d\u306f\u5ef6\u3073\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p>\u5341\u5206\u306a\u7761\u7720\u3084\u9069\u5ea6\u306a\u904b\u52d5\u3001\u30b9\u30c8\u30ec\u30b9\u306e\u7ba1\u7406\u306f\u3001\u514d\u75ab\u30d0\u30e9\u30f3\u30b9\uff1d\u5bdb\u5bb9\u306e\u7dad\u6301\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002\u305d\u3046\u3057\u305f\u65e5\u3005\u306e\u5fc3\u304c\u3051\u304c\u3001\u5c06\u6765\u7684\u306a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3084\u30a2\u30ec\u30eb\u30ae\u30fc\u3001\u3055\u3089\u306b\u306f\u5fc3\u306e\u4e0d\u8abf\u306e\u4e88\u9632\u306b\u3082\u3064\u306a\u304c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p>\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u304c\u6301\u3064\u7d20\u6674\u3089\u3057\u3044\u300c\u5bdb\u5bb9\u300d\u306e\u529b\u306b\u611f\u8b1d\u3057\u3064\u3064\u3001\u81ea\u5206\u306e\u4f53\u3068\u5fc3\u3092\u5927\u5207\u306b\u3057\u3066\u3044\u304d\u305f\u3044\u3067\u3059\u306d\u3002<\/p>\n\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -internal\" data-type=\"type1\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">\u3042\u308f\u305b\u3066\u8aad\u307f\u305f\u3044<\/span>\n\t\t\t\t\t<div class=\"p-blogCard__thumb c-postThumb\"><figure class=\"c-postThumb__figure\"><img decoding=\"async\" src=\"https:\/\/dr-kosodate-ns.com\/wp-content\/uploads\/2025\/05\/ChatGPT-Image-2025\u5e745\u67087\u65e5-00_04_06-300x179.png\" alt=\"\" class=\"c-postThumb__img u-obf-cover\" width=\"320\" height=\"180\"><\/figure><\/div>\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/dr-kosodate-ns.com\/?p=107\">\u5b50\u3069\u3082\u306e\u7761\u7720\u3000\uff5e\u307e\u3068\u3081\u8a18\u4e8b\uff5e<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">\u3010\u7cbe\u795e\u79d1\u533b\u304c\u89e3\u8aac\u3011\u8133\u3068\u5fc3\u306e\u767a\u9054\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u5b50\u3069\u3082\u306e\u7761\u7720\u3002\u30b7\u30ea\u30fc\u30ba\u3092\u901a\u3057\u3066\u5e74\u9f62\u3054\u3068\u306e\u8981\u70b9\u3092\u307e\u3068\u3081\u307e\u3057\u305f\u3002<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n<div class=\"swell-block-postLink\">\t\t\t<div class=\"p-blogCard -internal\" data-type=\"type1\" data-onclick=\"clickLink\">\n\t\t\t\t<div class=\"p-blogCard__inner\">\n\t\t\t\t\t<span class=\"p-blogCard__caption\">\u3042\u308f\u305b\u3066\u8aad\u307f\u305f\u3044<\/span>\n\t\t\t\t\t<div class=\"p-blogCard__thumb c-postThumb\"><figure class=\"c-postThumb__figure\"><img decoding=\"async\" src=\"https:\/\/dr-kosodate-ns.com\/wp-content\/uploads\/2025\/09\/ChatGPT-Image-2025\u5e749\u67081\u65e5-14_31_22-300x300.png\" alt=\"\" class=\"c-postThumb__img u-obf-cover\" width=\"320\" height=\"180\"><\/figure><\/div>\t\t\t\t\t<div class=\"p-blogCard__body\">\n\t\t\t\t\t\t<a class=\"p-blogCard__title\" href=\"https:\/\/dr-kosodate-ns.com\/?p=403\">\u304d\u3063\u3068\u3042\u306a\u305f\u306b\u3082\u5f53\u3066\u306f\u307e\u308b\u3001\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u300c\u5fc3\u3092\u5b88\u308b\u4ed5\u7d44\u307f\u300d\u3092\u7406\u89e3\u3057\u3088\u3046\uff1a\u5fc3\u7406\u7684\u9632\u885b\u6a5f\u5236\uff1c\u7dcf\u8ad6\uff1e<\/a>\n\t\t\t\t\t\t<span class=\"p-blogCard__excerpt\">\u3053\u3093\u306b\u3061\u306f\u3001Dr.\u6d41\u661f\u3067\u3059\u3002 \u4eca\u65e5\u306f\u65e5\u3054\u308d\u304b\u3089\u8ab0\u3082\u304c\u5fc3\u5f53\u305f\u308a\u304c\u3042\u308b\u3067\u3042\u308d\u3046\u3001\u30b9\u30c8\u30ec\u30b9\u304b\u3089\u7121\u81ea\u899a\u306b\u81ea\u5206\u3092\u5b88\u308b\u3068\u304d\u306b\u306f\u305f\u3089\u304f\u9632\u885b\u6a5f\u5236\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u304a\u8a71\u3057\u305f\u3044\u3068\u601d\u3044\u307e&#8230;<\/span>\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\n<div class=\"swell-block-accordion is-style-main\">\n<details class=\"swell-block-accordion__item\" data-swl-acc=\"wrapper\"><summary class=\"swell-block-accordion__title\" data-swl-acc=\"header\"><span class=\"swell-block-accordion__label\">\u53c2\u8003\u6587\u732e\u30fb\u60c5\u5831\u6e90<\/span><span class=\"swell-block-accordion__icon c-switchIconBtn\" data-swl-acc=\"icon\" aria-hidden=\"true\" data-opened=\"false\"><i class=\"__icon--closed icon-caret-down\"><\/i><i class=\"__icon--opened icon-caret-up\"><\/i><\/span><\/summary><div class=\"swell-block-accordion__body\" data-swl-acc=\"body\">\n<h5 class=\"wp-block-heading\">\u516c\u5f0f\u767a\u8868\u30fb\u4e00\u6b21\u60c5\u5831<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Nobel Prize Outreach. \u201cPress release: The Nobel Prize in Physiology or Medicine 2025.\u201d (2025-10-06). <a>https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/press-release\/<\/a><\/li>\n\n\n\n<li>Nobel Prize Outreach. \u201cPress release (PDF): The Nobel Prize in Physiology or Medicine 2025.\u201d (2025-10-06). <a>https:\/\/www.nobelprize.org\/uploads\/2025\/10\/press-medicineprize2025.pdf<\/a><\/li>\n\n\n\n<li>Nobel Prize Outreach. \u201cMary E. Brunkow \u2013 Facts (2025).\u201d <a>https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/brunkow\/facts\/<\/a><\/li>\n\n\n\n<li>Nobel Prize Outreach. \u201cShimon Sakaguchi \u2013 Facts (2025).\u201d <a>https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/sakaguchi\/facts\/<\/a><\/li>\n\n\n\n<li>Nobel Prize Outreach. \u201cPopular information: The Nobel Prize in Physiology or Medicine 2025.\u201d <a>https:\/\/www.nobelprize.org\/prizes\/medicine\/2025\/popular-information\/<\/a><\/li>\n\n\n\n<li>Nature Collection. \u201cNobel Prize in Physiology or Medicine 2025.\u201d <a href=\"https:\/\/www.nature.com\/collections\/ihgdffibdj?utm_source=chatgpt.com\">https:\/\/www.nature.com\/collections\/ihgdffibdj<\/a><\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">\u539f\u8457\u30fb\u53e4\u5178\u7684\u4e3b\u8981\u8ad6\u6587\uff08Treg \/ FOXP3 \/ \u672b\u68a2\u5bdb\u5bb9\uff09<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. \u201cImmunologic self-tolerance maintained by activated T cells expressing IL-2 receptor \u03b1-chains (CD25).\u201d <em>J Immunol.<\/em> 1995;155(3):1151\u20131164. PMID: 7636184. <a>https:\/\/pubmed.ncbi.nlm.nih.gov\/7636184\/<\/a><\/li>\n\n\n\n<li>Brunkow ME, Jeffery EW, Hjerrild KA, et al. \u201cDisruption of a new forkhead\/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.\u201d <em>Nat Genet.<\/em> 2001;27(1):68\u201373. <a href=\"https:\/\/www.nature.com\/articles\/ng0101_68?utm_source=chatgpt.com\">https:\/\/www.nature.com\/articles\/ng0101_68<\/a> \/ PubMed: <a>https:\/\/pubmed.ncbi.nlm.nih.gov\/11138001\/<\/a><\/li>\n\n\n\n<li>Bennett CL, Christie J, Ramsdell F, et al. \u201cThe immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.\u201d <em>Nat Genet.<\/em> 2001;27(1):20\u201321. <a href=\"https:\/\/www.nature.com\/articles\/ng0101_20?utm_source=chatgpt.com\">https:\/\/www.nature.com\/articles\/ng0101_20<\/a> \/ PubMed: <a>https:\/\/pubmed.ncbi.nlm.nih.gov\/11137993\/<\/a><\/li>\n\n\n\n<li>Hori S, Nomura T, Sakaguchi S. \u201cControl of regulatory T cell development by the transcription factor Foxp3.\u201d <em>Science.<\/em> 2003;299(5609):1057\u20131061. PubMed: <a>https:\/\/pubmed.ncbi.nlm.nih.gov\/12522256\/<\/a> \/ <a>https:\/\/www.science.org\/doi\/10.1126\/science.1079490<\/a><\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">\u7dcf\u8aac\u30fb\u30ec\u30d3\u30e5\u30fc\uff08\u672b\u68a2\u5bdb\u5bb9\u30fbTreg\u30fb\u53e3\u8154\u5bdb\u5bb9 \u7b49\uff09<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sakaguchi S, Yamaguchi T, Nomura T, Ono M. \u201cRegulatory T cells and immune tolerance.\u201d <em>Cell.<\/em> 2008;133(5):775\u2013787. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867408006247?utm_source=chatgpt.com\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867408006247<\/a><\/li>\n\n\n\n<li>Vignali DAA, Collison LW, Workman CJ. \u201cHow regulatory T cells work.\u201d <em>Nat Rev Immunol.<\/em> 2008;8(7):523\u2013532. 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PMC: <a>https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11188918\/<\/a><\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">\u516c\u7684\u6a5f\u95a2\u30fb\u5b66\u8853\u6a5f\u95a2\u306e\u89e3\u8aac<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NIAID\/NIH. \u201cImmune Tolerance.\u201d <a>https:\/\/www.niaid.nih.gov\/research\/immune-tolerance<\/a><\/li>\n\n\n\n<li>NIAID\/NIH. \u201cImmune Tolerance Processes in Autoimmune Disease.\u201d (2025-03-18). <a>https:\/\/www.niaid.nih.gov\/diseases-conditions\/immune-tolerance-processes-autoimmune-disease<\/a><\/li>\n\n\n\n<li>NCI\/NIH. \u201cRegulatory T cell \u2014 NCI Dictionary of Cancer Terms.\u201d <a>https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/regulatory-t-cell<\/a><\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">\u53c2\u8003\uff1a\u5831\u9053\uff08\u53d7\u8cde\u4e8b\u5b9f\u306e\u78ba\u8a8d\u7528\uff09<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Associated Press. \u201cThe Nobel Prize in medicine goes to 3 scientists for key immune system discoveries.\u201d (2025-10-06). <a>https:\/\/apnews.com\/article\/nobel-prize-medicine-a68cf8a3b930570630168a949d277cde<\/a><\/li>\n\n\n\n<li>The Wall Street Journal. \u201cTrio Wins Nobel Prize in Medicine for Discoveries on Immune System.\u201d (2025-10-07). <a>https:\/\/www.wsj.com\/science\/trio-wins-nobel-prize-in-medicine-for-discoveries-on-immune-system-0b566e73<\/a><\/li>\n\n\n\n<li>University of Washington News. \u201cUW alum Mary E. Brunkow awarded the 2025 Nobel Prize in Physiology or Medicine.\u201d (2025-10-06). <a>https:\/\/www.washington.edu\/news\/2025\/10\/06\/uw-alum-mary-e-brunkow-awarded-the-2025-nobel-prize-in-physiology-or-medicine\/<\/a><\/li>\n\n\n\n<li>UCLA Health Newsroom. \u201cUCLA alumnus Fred Ramsdell wins 2025 Nobel Prize in physiology or medicine.\u201d (2025-10-06). <a>https:\/\/www.uclahealth.org\/news\/release\/ucla-alumnus-fred-ramsdell-wins-2025-nobel-prize-physiology<\/a><\/li>\n<\/ul>\n<\/div><\/details>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u73fe\u5f79\u533b\u5e2b\u304c\u89e3\u8aac\u30112025\u5e74\u30ce\u30fc\u30d9\u30eb\u751f\u7406\u5b66\u30fb\u533b\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u305f\u3001\u300c\u672b\u68a2\u6027\u514d\u75ab\u5bdb\u5bb9\u300d\u306b\u95a2\u3059\u308b\u7814\u7a76\u3002\u305d\u306e\u5185\u5bb9\u3092\u512a\u3057\u304f\u89e3\u8aac\u3002\u7cbe\u795e\u795e\u7d4c\u79d1\u9818\u57df\u3068\u306e\u95a2\u9023\u3082\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n","protected":false},"author":1,"featured_media":446,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"swell_btn_cv_data":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[104],"tags":[108,106,107,105],"class_list":["post-441","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-104","tag-t","tag-106","tag-107","tag-105"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/dr-kosodate-ns.com\/wp-content\/uploads\/2025\/10\/\u5236\u5fa1\u6027T\u7d30\u80de\u3068\u306f\uff1f.png","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=\/wp\/v2\/posts\/441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=441"}],"version-history":[{"count":4,"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=\/wp\/v2\/posts\/441\/revisions"}],"predecessor-version":[{"id":447,"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=\/wp\/v2\/posts\/441\/revisions\/447"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=\/wp\/v2\/media\/446"}],"wp:attachment":[{"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dr-kosodate-ns.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}